Meet the Innovators Under 35

Cigall Kadoch, Dana-Farber Cancer Institute and Harvard Medical School

A major vulnerability of certain kinds of cancer is becoming clear.

Cigall Kadoch, Assistant Professor, Dana-Farber Cancer Institute and Harvard Medical School

Cigall Kadoch is an assistant professor of pediatric oncology at the Dana-Farber Cancer Institute and Harvard Medical School and an Institute Member of the Broad Institute of MIT and Harvard. While completing her PhD at Stanford, Kadoch discovered a link between a genome regulator in cells, called the BAF protein complex, and a rare cancer called synovial sarcoma. She and colleagues later showed that mutations of BAF are involved in at least 20 percent of human cancers, opening the door for research on drugs that target mutated BAFs. She is now applying innovative approaches to structurally and functionally study chromatin regulators and develop therapeutic approaches for cancers driven by BAF mutations. Kadoch earned her undergraduate degree in molecular and cell biology from the University of California, Berkeley, and her PhD in cancer biology from the Stanford University School of Medicine. She is the recipient of many honors, including the NIH Director’s New Innovator Award and the Pew-Stewart Scholar in Cancer Research Award.

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Innovators Under 35
individuals whose superb technical work promises to shape the coming decades through the development of new technology or the creative application of existing technologies to solve problems.